Koivisto, KaroliinaPuhakka, LauraLappalainen, MaijaBlomqvist, SoileSaxen, HarriNieminen, Tea2018-06-062025-08-272017-03-14Koivisto, K, Puhakka, L, Lappalainen, M, Blomqvist, S, Saxen, H & Nieminen, T 2017, 'Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015', Vaccine, vol. 35, no. 12, pp. 1608-1614. https://doi.org/10.1016/j.vaccine.2017.02.018ORCID: /0000-0001-5400-1250/work/33744811http://hdl.handle.net/10138/235564Healthcare workers (HCWs) pose a risk to themselves and their patients if not protected against vaccine preventable diseases. Alarmingly, lacking immunity has been reported in several studies. We assessed the immunity against vaccine-preventable diseases in 157 pediatric HCWs in Helsinki Children's Hospital. The HCWs enrolled answered a questionnaire and gave a serum sample. Antibodies were measured with EIA against MMR-diseases, tetanus and diphtheria toxins, Hepatitis B (HBV), Hepatitis A (HAV), varicella zoster and pertussis toxin. Neutralizing antibodies against poliovirus 1, 2 and 3 were measured. All of the HCWs had antibodies against tetanus and 89.8% against diphtheria. All had measurable levels of polio antibodies to all three polioviruses. 41% had suboptimal levels of antibodies against at least one of the antigens tested: MMR-viruses, diphtheria, HBV or polio. Measles, mumps and rubella antibodies were detectable in 81.5%, 89.2% and 93%, respectively. Only one HCW had no varicella-antibodies. Hepatitis B surface antibodies (HBsAb) were detected in 89.8% of the nurses. 67.5% had HAV-antibodies. A poor correlation between detected antibody levels and reported vaccination history was noticed, indicating a need for a universal record system for registering the vaccines given to each individual. (C) 2017 Elsevier Ltd. All rights reserved.7enginfo:eu-repo/semantics/openAccessImmunityVaccinationVaccine-preventable diseasesHealthcare workersPERTUSSIS BOOSTER VACCINATIONMUMPS-RUBELLA VACCINEHEPATITIS-BMEASLESSUSCEPTIBILITYANTIBODIESSEROPREVALENCEIMMUNIZATIONPERSISTENCEPREVALENCEBiomedicineArticleopenAccess2d76a4e1-5d39-4607-a2bb-7c196741800985013218997000396958400006