Makela, Mikko K.Bulatov, EvgenyMalinen, KiiaTalvitie, JuuliaNieger, MartinMelchionna, MicheleLenarda, AnnaHu, TaoWirtanen, TomHelaja, Juho2021-08-182021-08-182021-08-03Makela, M K, Bulatov, E, Malinen, K, Talvitie, J, Nieger, M, Melchionna, M, Lenarda, A, Hu, T, Wirtanen, T & Helaja, J 2021, 'Carbocatalytic Cascade Synthesis of Polysubstituted Quinolines from Aldehydes and 2-Vinyl Anilines', Advanced Synthesis & Catalysis, vol. 363, no. 15, pp. 3775-3782. https://doi.org/10.1002/adsc.202100711ORCID: /0000-0003-1677-0109/work/98655586ORCID: /0000-0003-1200-1978/work/98658421ORCID: /0000-0003-1571-9790/work/106341562http://hdl.handle.net/10138/333264Oxidized active carbon (oAC) catalyses the formation of polysubstituted quinolines from o-vinyl anilines and aldehydes. The reaction proceeds in a cascade manner through condensation, electrocyclization and dehydrogenation, and gives access to a wide range of quinolines with alkyl and/or aryl substituents as demonstrated with 40 examples. The metal-free catalytic procedure allows a heterogeneous protocol for the synthesis of various polysubstituted quinolines. The mechanistic studies imply that both the acid and quinoidic groups in oAC are integral for the catalytic manifold.8engcc_byinfo:eu-repo/semantics/openAccessChemical sciencesCarbocatalysisQuinolineOxidative DehydrogenationElectrocyclizationACTIVATED CARBONOXIDATIVE AROMATIZATIONGRAPHENE OXIDEMICHAEL ADDITIONDEHYDROGENATIONCHEMISTRYMECHANISMEFFICIENTSYSTEMAMINESArticleopenAccess737f311f-8933-4a9f-89c8-09fdb1741714000672885500001