TY  -  
T1  - β-Amyloid Targeting with Two-Dimensional Covalent Organic Frameworks : Multi-Scale In-Silico Dissection of Nano-Biointerface 
SN  -  /  
UR  - http://hdl.handle.net/10138/332943 
T3  -  
A1  - Maleki, Reza; Khedri, Mohammad; Rezvantalab, Sima; Afsharchi, Fatemeh; Musaie, Kiyan; Shafiee, Sepehr; Shahbazi, Mohammad-Ali 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Cytotoxic aggregation of misfolded beta-amyloid (A beta) proteins is the main culprit suspected to be behind the development of Alzheimer's disease (AD). In this study, A beta interactions with the novel two-dimensional (2D) covalent organic frameworks (COFs) as therapeutic options for avoiding beta-amyloid aggregation have been investigated. The results from multi-scale atomistic simulations suggest that amine-functionalized COFs with a large surface area (more than 1000 m(2)/gr) have the poten... 
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IS  -  
SP  -  
OP  -  
KW  - 2D materials; Alzheimer's disease; β-amyloid; covalent organic frameworks; molecular simulation; ALZHEIMERS-DISEASE; GOLD NANOPARTICLES; GRAPHENE OXIDE; ELECTRIC-FIELD; AGGREGATION; INHIBITION; PEPTIDE; NEUROTOXICITY; FIBRILLATION; CLEARANCE; 318 Medical biotechnology; 221 Nano-technology 
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PP  -  
ER  -