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T1  - 2BC Non-Structural Protein of Enterovirus A71 Interacts with SNARE Proteins to Trigger Autolysosome Formation 
SN  -  /  
UR  - http://hdl.handle.net/10138/215603 
T3  -  
A1  - Lai, Jeffrey K. F.; Sam, I-Ching; Verlhac, Pauline; Baguet, Joel; Eskelinen, Eeva-Liisa; Faure, Mathias; Chan, Yoke Fun 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Viruses have evolved unique strategies to evade or subvert autophagy machinery. Enterovirus A71 (EV-A71) induces autophagy during infection in vitro and in vivo. In this study, we report that EV-A71 triggers autolysosome formation during infection in human rhabdomyosarcoma (RD) cells to facilitate its replication. Blocking autophagosome-lysosome fusion with chloroquine inhibited virus RNA replication, resulting in lower viral titres, viral RNA copies and viral proteins. Overexpression of the non... 
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KW  - picornavirus; enterovirus; enterovirus A71; replication; autophagy; autolysosome; syntaxin-17; synaptosome-associated protein of 29 kDa; SNARE; 2BC; AUTOPHAGOSOME-LYSOSOME FUSION; POLIOVIRUS REPLICATION COMPLEX; SYNTAXIN 17; VIRUS-REPLICATION; HOPS COMPLEX; INHIBITORS; MACHINERY; CELLS; MECHANISMS; MATURATION; 1183 Plant biology, microbiology, virology 
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