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T1  - A Microfluidic Chip Architecture Enabling a Hypoxic Microenvironment and Nitric Oxide Delivery in Cell Culture 
SN  -  /  
UR  - http://hdl.handle.net/10138/325722 
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A1  - Barmaki, Samineh; Obermaier, Daniela; Kankuri, Esko; Vuola, Jyrki; Franssila, Sami; jokinen, Ville 
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PB  -  
Y1  - 2020 
LA  - eng 
AB  - A hypoxic (low oxygen level) microenvironment and nitric oxide paracrine signaling play important roles in the control of both biological and pathological cell responses. In this study, we present a microfluidic chip architecture for nitric oxide delivery under a hypoxic microenvironment in human embryonic kidney cells (HEK-293). The chip utilizes two separate, but interdigitated microfluidic channels. The hypoxic microenvironment was created by sodium sulfite as the oxygen scavenger in one of t... 
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KW  - DEVICES; DIFFUSION; OXYGEN GRADIENTS; PLATFORM; cell culture; gasotransmitter; hypoxia; microenvironment; microfluidic chip; nitric oxide; oxygen depletion; sodium nitroprusside; 3111 Biomedicine 
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