TY  -  
T1  - A Na,K-ATPase-Fodrin-Actin Membrane Cytoskeleton Complex is Required for Endothelial Fenestra Biogenesis 
SN  -  /  
UR  - http://hdl.handle.net/10138/321030 
T3  -  
A1  - Ju, Meihua; Ioannidou, Sofia; Munro, Peter; Rämö, Olli; Vihinen, Helena; Jokitalo, Eija; Shima, David T. 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Fenestrae are transcellular plasma membrane pores that mediate blood-tissue exchange in specialised vascular endothelia. The composition and biogenesis of the fenestra remain enigmatic. We isolated and characterised the protein composition of large patches of fenestrated plasma membrane, termed sieve plates. Loss-of-function experiments demonstrated that two components of the sieve plate, moesin and annexin II, were positive and negative regulators of fenestra formation, respectively. Biochemica... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - fenestrae; moesin; annexin II; actin; fodrin; Na; K-ATPase; submembrane cytoskeleton; NA+,K+-ATPASE ALPHA-SUBUNIT; ERYTHROCYTE-MEMBRANE; GROWTH-FACTOR; ACTIN CYTOSKELETON; NA+/K+-ATPASE; PROTEIN; SPECTRIN; PERMEABILITY; BINDING; OUABAIN; 1182 Biochemistry, cell and molecular biology 
N1  -   
PP  -  
ER  -