TY - T1 - A Perspective : Active Role of Lipids in Neurotransmitter Dynamics SN - / UR - http://hdl.handle.net/10138/312179 T3 - A1 - Postila, Pekka A.; Róg, Tomasz A2 - PB - Y1 - 2020 LA - eng AB - Synaptic neurotransmission is generally considered as a function of membrane-embedded receptors and ion channels in response to the neurotransmitter (NT) release and binding. This perspective aims to widen the protein-centric view by including another vital component—the synaptic membrane—in the discussion. A vast set of atomistic molecular dynamics simulations and biophysical experiments indicate that NTs are divided into membrane-binding and membrane-nonbinding categories. The binary choice ta... VO - IS - SP - OP - KW - CRYSTAL-STRUCTURES; DOPAMINE TRANSPORTER; FREE-ENERGY PROFILE; HYDROGEN-SULFIDE; MEMBRANE-LIPIDS; Membrane lipid composition (MLC); Membrane-based sorting; Molecular dynamics (MD); NERVOUS-SYSTEM; NITRIC-OXIDE DIFFUSION; Neurotransmitter; PLASMA-MEMBRANE; SYNAPTIC VESICLE; Synaptic neurotransmission; Synaptic receptor; X-RAY STRUCTURES; 1182 Biochemistry, cell and molecular biology N1 - PP - ER -