TY - T1 - A Reductive Metabolic Switch Protects Infants with Transposition of Great Arteries Undergoing Atrial Septostomy against Oxidative Stress SN - / UR - http://hdl.handle.net/10138/334610 T3 - A1 - Piñeiro-Ramos, José David; Rahkonen, Otto; Korpioja, Virpi; Quintás, Guillermo; Pihkala, Jaana; Pitkänen-Argillander, Olli; Rautiainen, Paula; Andersson, Sture; Kuligowski, Julia; Vento, Máximo A2 - PB - Multidisciplinary Digital Publishing Institute Y1 - 2021 LA - AB - Transposition of the great arteries (TGA) is one of the most common cyanotic congenital heart diseases requiring neonatal surgical intervention. Parallel circulations that result in impaired cerebral oxygen delivery already in utero may lead to brain damage and long-term neurodevelopmental delay. Balloon atrial septostomy (BAS) is often employed to mix deoxygenated and oxygenated blood at the atrial level. However, BAS causes a sudden increase in arterial blood oxygenation and oxidative stress. ... VO - IS - SP - OP - KW - N1 - PP - ER -