TY  -  
T1  - A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion 
SN  -  /  
UR  - http://hdl.handle.net/10138/204689 
T3  -  
A1  - Narva, Elisa; Stubb, Aki; Guzman, Camilo; Blomqvist, Matias; Balboa, Diego; Lerche, Martina; Saari, Markku; Otonkoski, Timo; Ivaska, Johanna 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Cell-type-specific functions and identity are tightly regulated by interactions between the cell cytoskeleton and the extracellular matrix (ECM). Human pluripotent stem cells (hPSCs) have ultimate differentiation capacity and exceptionally low-strength ECM contact, yet the organization and function of adhesion sites and associated actin cytoskeleton remain poorly defined. We imaged hPSCs at the cell-ECM interface with total internal reflection fluorescence microscopy and discovered that adhesion... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - EMBRYONIC STEM-CELLS; SELF-RENEWAL; RECOMBINANT VITRONECTIN; INTEGRIN; SRC; RHO; DIFFERENTIATION; CULTURE; ORGANIZATION; EXPANSION; 3111 Biomedicine 
N1  -   
PP  -  
ER  -