TY - T1 - A comparative analysis of parechovirus protein structures with other picornaviruses SN - / UR - http://hdl.handle.net/10138/333238 T3 - A1 - Domanska, Ausra; Guryanov, Sergey; Butcher, Sarah J. A2 - PB - Y1 - 2021 LA - eng AB - Parechoviruses belong to the genus Parechovirus within the family Picornaviridae and are non-enveloped icosahedral viruses with a single-stranded RNA genome. Parechoviruses include human and animal pathogens classified into six species. Those that infect humans belong to the Parechovirus A species and can cause infections ranging from mild gastrointestinal or respiratory illness to severe neonatal sepsis. There are no approved antivirals available to treat parechovirus (nor any other picornaviru... VO - IS - SP - OP - KW - picornavirus; parechovirus; structure; RNA stem-loop; function; POLIOVIRUS POLYPEPTIDE 3CD; DEPENDENT RNA-POLYMERASE; COMMON COLD VIRUS; CRYSTAL-STRUCTURE; MEMBRANE PERMEABILIZATION; GENOMIC CHARACTERIZATION; ENTEROVIRUS REPLICATION; NUCLEOTIDE-SEQUENCE; ATP HYDROLYSIS; LJUNGAN VIRUS; 1182 Biochemistry, cell and molecular biology N1 - PP - ER -