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T1  - A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling 
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UR  - http://hdl.handle.net/10138/204071 
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A1  - Li, Dong; Chang, Xiao; Connolly, John J.; Tian, Lifeng; Liu, Yichuan; Bhoj, Elizabeth J.; Robinson, Nora; Abrams, Debra; Li, Yun R.; Bradfield, Jonathan P.; Kim, Cecilia E.; Li, Jin; Wang, Fengxiang; Snyder, James; Lemma, Maria; Hou, Cuiping; Wei, Zhi; Guo, Yiran; Qiu, Haijun; Mentch, Frank D.; Thomas, Kelly A.; Chiavacci, Rosetta M.; Cone, Roger; Li, Bingshan; Sleiman, Patrick A.; Hakonarson, Hakon; Eating Disorders Working Group of the Psychiatric Genomics Consortium; Kaprio, Jaakko; Palotie, Aarno; Raevuori-Helkamaa, Anu; Ripatti, Samuli; Price Fdn Collaborative Grp 
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Y1  - 2017 
LA  - eng 
AB  - We conducted a genome-wide association study (GWAS) of anorexia nervosa (AN) using a stringently defined phenotype. Analysis of phenotypic variability led to the identification of a specific genetic risk factor that approached genome-wide significance (rs929626 in EBF1 (Early B-Cell Factor 1); P = 2.04 x 10(-7); OR = 0.7; 95% confidence interval (CI) = 0.61-0.8) with independent replication (P = 0.04), suggesting a variant-mediated dysregulation of leptin signaling may play a role in AN. Multipl... 
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KW  - OBSESSIVE-COMPULSIVE DISORDER; B-CELL-FACTOR; EATING-DISORDERS; GENETICS; PARAMETERS; VARIANTS; PRESSURE; CHILDREN; EBF1; 3124 Neurology and psychiatry; 3142 Public health care science, environmental and occupational health 
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