TY  -  
T1  - A high definition picture of somatic mutations in chronic lymphoproliferative disorder of natural killer cells 
SN  -  /  
UR  - http://hdl.handle.net/10138/315266 
T3  -  
A1  - Gasparini, Vanessa Rebecca; Binatti, Andrea; Coppe, Alessandro; Teramo, Antonella; Vicenzetto, Cristina; Calabretto, Giulia; Barila, Gregorio; Barizza, Annica; Giussani, Edoardo; Facco, Monica; Mustjoki, Satu; Semenzato, Gianpietro; Zambello, Renato; Bortoluzzi, Stefania 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - The molecular pathogenesis of chronic lymphoproliferative disorder of natural killer (NK) cells (CLPD-NK) is poorly understood. Following the screening of 57 CLPD-NK patients, only five presented STAT3 mutations. WES profiling of 13 cases negative for STAT3/STAT5B mutations uncovered an average of 18 clonal, population rare and deleterious somatic variants per patient. The mutational landscape of CLPD-NK showed that most patients carry a heavy mutational burden, with major and subclonal deleteri... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - STAT3 MUTATIONS; GENOMIC LANDSCAPE; PATHOGENESIS; LEUKEMIA; TET2; HEMATOPOIESIS; GENETICS; DISEASE; 3122 Cancers 
N1  -   
PP  -  
ER  -