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T1  - A machine-learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes 
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UR  - http://hdl.handle.net/10138/256029 
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A1  - Kringel, D.; Lippmann, C.; Parnham, M. J.; Kalso, E.; Ultsch, A.; Lötsch, J. 
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Y1  - 2018 
LA  - eng 
AB  - Background Human genetic research has implicated functional variants of more than one hundred genes in the modulation of persisting pain. Artificial intelligence and machine-learning techniques may combine this knowledge with results of genetic research gathered in any context, which permits the identification of the key biological processes involved in chronic sensitization to pain. MethodsResultsBased on published evidence, a set of 110 genes carrying variants reported to be associated with mo... 
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KW  - INTERLEUKIN-1 RECEPTOR ANTAGONIST; IRRITABLE-BOWEL-SYNDROME; VULVAR VESTIBULITIS SYNDROME; LUMBAR DISC DISEASE; POSTHERPETIC NEURALGIA PHN; CYCLOHYDROLASE 1 HAPLOTYPE; DATA SCIENCE APPROACH; LOW-BACK-PAIN; NITRIC-OXIDE; KNEE OSTEOARTHRITIS; 3126 Surgery, anesthesiology, intensive care, radiology 
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