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T1  - A metabolomic approach to studying mechanisms of polymeric gene delivery to retinal pigment epithelial cells 
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UR  - URN:NBN:fi-fe201801151126; http://hdl.handle.net/10138/26645 
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A1  - Holma, Paula 
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PB  - Helsingfors universitet 
Y1  - 2011 
LA  - eng 
AB  - Metabolomics is a rapidly growing research field that studies the response of biological systems to environmental factors, disease states and genetic modifications. It aims at measuring the complete set of endogenous metabolites, i.e. the metabolome, in a biological sample such as plasma or cells. Because metabolites are the intermediates and end products of biochemical reactions, metabolite compositions and metabolite levels in biological samples can provide a wealth of information on on-going ... 
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KW  - gene delivery; non-viral vector; metabolomics; metabolite; liquid chromatography; mass spectrometry; data analysis; principal component analysis; Farmaceutisk kemi; Pharmaceutical Chemistry; Farmaseuttinen kemia 
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