TY  -  
T1  - A new approach to prepare amorphous solid dispersions of indomethacin and PVPVA : spray drying from aqueous phase 
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UR  - URN:NBN:fi:hulib-202012225478; http://hdl.handle.net/10138/323617 
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A1  - Kainulainen, Saila 
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PB  - Helsingin yliopisto 
Y1  - 2020 
LA  - eng 
AB  - The solubility of a poorly water-soluble drug can be improved by converting the crystalline drug into an amorphous form. However, the amorphous form is metastable due to the higher energy state and recrystallization may occur during storage and dissolution. The amorphous form can be stabilized by forming an amorphous solid dispersion (ASD), where the drug molecules are dispersed to the solid medium, e.g. hydrophilic polymer. One preparation method for amorphous solid dispersions is spray drying,... 
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KW  - amorphous solid dispersion; spray drying; indomethacin; PVPVA; x-ray powder diffraction; surface plasmon resonance; Farmasian teknologia; Pharmaceutical technology; Farmaceutisk teknologi ; Proviisorin koulutusohjelma; Master's Programme in Pharmacy; Utbildningsprogrammet för provisorexamen 
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