TY  -  
T1  - A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses 
SN  -  /  
UR  - http://hdl.handle.net/10138/304093 
T3  -  
A1  - Abdelnabi, Rana; Geraets, James A.; Ma, Yipeng; Mirabelli, Carmen; Flatt, Justin W.; Domanska, Ausra; Delang, Leen; Jochmans, Dirk; Kumar, Timiri Ajay; Jayaprakash, Venkatesan; Sinha, Barij Nayan; Leyssen, Pieter; Butcher, Sarah J.; Neyts, Johan 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Rhino- and enteroviruses are important human pathogens, against which no antivirals are available. The best-studied inhibitors are capsid binders that fit in a hydrophobic pocket of the viral capsid. Employing a new class of entero-/rhinovirus inhibitors and by means of cryo-electron microscopy (EM), followed by resistance selection and reverse genetics, we discovered a hitherto unknown druggable pocket that is formed by viral proteins VP1 and VP3 and that is conserved across entero-/rhinovirus ... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - COXSACKIEVIRUS B3; INHIBITOR; PROTEIN; REPLICATION; 1182 Biochemistry, cell and molecular biology 
N1  -   
PP  -  
ER  -