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T1  - A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes : results from an exome-wide association study of albuminuria 
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UR  - http://hdl.handle.net/10138/298740 
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A1  - Ahluwalia, Tarunveer S.; Schulz, Christina-Alexandra; Waage, Johannes; Skaaby, Tea; Sandholm, Niina; van Zuydam, Natalie; Charmet, Romain; Bork-Jensen, Jette; Almgren, Peter; Thuesen, Betina H.; Bedin, Mathilda; Brandslund, Ivan; Christensen, Cramer K.; Linneberg, Allan; Ahlqvist, Emma; Groop, Per-Henrik; Hadjadj, Samy; Tregouet, David-Alexandre; Jorgensen, Marit E.; Grarup, Niels; Pedersen, Oluf; Simons, Matias; Groop, Leif; Orho-Melander, Marju; McCarthy, Mark I.; Melander, Olle; Rossing, Peter; Kilpeläinen, Tuomas O.; Hansen, Torben 
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Y1  - 2019 
LA  - eng 
AB  - Aims/hypothesisIdentifying rare coding variants associated with albuminuria may open new avenues for preventing chronic kidney disease and end-stage renal disease, which are highly prevalent in individuals with diabetes. Efforts to identify genetic susceptibility variants for albuminuria have so far been limited, with the majority of studies focusing on common variants.MethodsWe performed an exome-wide association study to identify coding variants in a two-stage (discovery and replication) appro... 
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KW  - Albuminuria; Diabetes; DKD; Exome chip; Genetics; Genome-wide association study; Kidney disease; GWAS; Rare variant; SKAT; Type 2 diabetes; GENOME-WIDE; KIDNEY-DISEASE; RISK; REVEALS; LOCI; METAANALYSIS; PROTECTION; RECEPTORS; DISCOVERY; FRAMEWORK; 3121 General medicine, internal medicine and other clinical medicine; 3111 Biomedicine; 1184 Genetics, developmental biology, physiology 
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