TY  -  
T1  - A physiologically validated rat model of term birth asphyxia with seizure generation after, not during, brain hypoxia 
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UR  - http://hdl.handle.net/10138/331433 
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A1  - Ala-Kurikka, Tommi; Pospelov, Alexey; Summanen, Milla; Alafuzoff, Aleksander; Kurki, Samu; Voipio, Juha; Kaila, Kai 
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PB  -  
Y1  - 2021 
LA  - eng 
AB  - Objective Birth asphyxia (BA) is often associated with seizures that may exacerbate the ensuing hypoxic-ischemic encephalopathy. In rodent models of BA, exposure to hypoxia is used to evoke seizures, that commence already during the insult. This is in stark contrast to clinical BA, in which seizures are typically seen upon recovery. Here, we introduce a term-equivalent rat model of BA, in which seizures are triggered after exposure to asphyxia. Methods Postnatal day 11-12 male rat pups were expo... 
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KW  - chemoreflex; hypercapnia; hypoxia; neonatal seizures; neuroprotection; perinatal asphyxia; INTRACELLULAR PH; INJURY; ELECTROENCEPHALOGRAM; POTENTIATION; ALKALOSIS; EVOLUTION; RESPONSES; EVENTS; BURDEN; RISK; 3112 Neurosciences 
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