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T1  - A wake-up call : Sleep physiology and related translational discrepancies in studies of rapid-acting antidepressants 
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UR  - http://hdl.handle.net/10138/334821 
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A1  - Alitalo, Okko; Saarreharju, Roosa; Henter, Ioline D.; Jr, Carlos A. Zarate; Kohtala, Samuel; Rantamäki, Tomi 
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Y1  - 2021 
LA  - eng 
AB  - Depression is frequently associated with sleep problems, and clinical improvement often coincides with the normalization of sleep architecture and realignment of circadian rhythm. The effectiveness of treatments targeting sleep in depressed patients, such as sleep deprivation, further demonstrates the confluence of sleep and mood. Moreover, recent studies showing that the rapid-acting antidepressant ketamine influences processes related to sleep-wake neurobiology have led to novel hypotheses exp... 
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KW  - Depression  Rapid-acting antidepressant; Sleep; Circadian  rhythm; Pharmacology; Translational  research; TREATMENT-RESISTANT DEPRESSION; COGNITIVE-BEHAVIORAL THERAPY; D-ASPARTATE ANTAGONIST; ELECTROCONVULSIVE-THERAPY; OPTOGENETIC STIMULATION; ORAL ANTIDEPRESSANT; CIRCADIAN-RHYTHM; KETAMINE; DEPRIVATION; PLASTICITY; 3112 Neurosciences; 317 Pharmacy 
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