TY  -  
T1  - ADAM15 gene structure and differential alternative exon use in human tissues 
SN  -  /  
UR  - http://hdl.handle.net/10138/298784 
T3  -  
A1  - Kleino, Iivari; Ortiz, Rebekka M.; Huovila, Ari-Pekka J. 
A2  -  
PB  -  
Y1  - 2007 
LA  - eng 
AB  - Background: ADAM15 is a metalloprotease-disintegrin implicated in ectodomain shedding and cell adhesion. Aberrant ADAM15 expression has been associated with human cancer and other disorders. We have previously shown that the alternative splicing of ADAM15 transcripts is mis-regulated in cancer cells. To gain a better understanding of ADAM15 regulation, its genomic organization and regulatory elements as well as the alternative exon use in human tissues were characterized. Results: Human ADAM15, ... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - PRE-MESSENGER-RNA; ENDOTHELIAL GROWTH-FACTOR; SRC FAMILY PROTEINS; REGULATORY ELEMENTS; BINDING PROTEINS; DNA-SEQUENCE; DISINTEGRIN-METALLOPROTEINASES; COMPUTATIONAL ANALYSIS; ALTERED EXPRESSION; CYTOPLASMIC DOMAIN; 1182 Biochemistry, cell and molecular biology 
N1  -   
PP  -  
ER  -