TY  -  
T1  - ALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors 
SN  -  /  
UR  - http://hdl.handle.net/10138/320153 
T3  -  
A1  - Kaipio, Katja; Chen, Ping; Roering, Pia; Huhtinen, Kaisa; Mikkonen, Piia; Östling, Päivi; Lehtinen, Laura; Mansuri, Naziha; Korpela, Taina; Potdar, Swapnil; Hynninen, Johanna; Auranen, Annika; Grénman, Seija; Wennerberg, Krister; Hautaniemi, Sampsa; Carpén, Olli 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Poor chemotherapy response remains a major treatment challenge for high-grade serous ovarian cancer (HGSC). Cancer stem cells are the major contributors to relapse and treatment failure as they can survive conventional therapy. Our objectives were to characterise stemness features in primary patient-derived cell lines, correlate stemness markers with clinical outcome and test the response of our cells to both conventional and exploratory drugs. Tissue and ascites samples, treatment-naive and/or ... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - 3122 Cancers; Ovarian cancer; stem-like cell; patient derived cell line; survival; drug sensitivity; CELLS; CONTRIBUTE; BMI-1; ovarian cancer; ALDEHYDE DEHYDROGENASE; MARKER; IDENTIFICATION; patient-derived cell line; MICROENVIRONMENT; EXPRESSION; EPITHELIAL OVARIAN; AURORA 
N1  -   
PP  -  
ER  -