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T1  - APOE epsilon 4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue : a Finnish biobank, autopsy and clinical study 
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UR  - http://hdl.handle.net/10138/338308 
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A1  - FinnGen; Kurki, Samu N.; Kantonen, Jonas; Kaivola, Karri; Hokkanen, Laura; Mäyranpää, Mikko I.; Puttonen, Henri; Martola, Juha; Pöyhönen, Minna; Kero, Mia; Tuimala, Jarno; Carpen, Olli; Kantele, Anu; Vapalahti, Olli; Tiainen, Marjaana; Tienari, Pentti J.; Kaila, Kai; Hastbacka, Johanna; Myllykangas, Liisa 
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Y1  - 2021 
LA  - eng 
AB  - Apolipoprotein E epsilon 4 allele (APOE4) has been shown to associate with increased susceptibility to SARS-CoV-2 infection and COVID-19 mortality in some previous genetic studies, but information on the role of APOE4 on the underlying pathology and parallel clinical manifestations is scarce. Here we studied the genetic association between APOE and COVID-19 in Finnish biobank, autopsy and prospective clinical cohort datasets. In line with previous work, our data on 2611 cases showed that APOE4 c... 
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KW  - APOE4; COVID-19 sequelae; Brain microhaemorrhage; Post-viral fatigue; Neuropathology; SARS-CoV-2; Biobank; APOE; NEUROPATHOLOGY; DISEASE; 3112 Neurosciences 
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