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T1  - ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons 
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UR  - http://hdl.handle.net/10138/238485 
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A1  - Hlushchenko, Iryna; Khanal, Pushpa; Abouelezz, Amr; Paavilainen, Ville O.; Hotulainen, Pirta 
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PB  -  
Y1  - 2018 
LA  - eng 
AB  - Many actin cytoskeleton-regulating proteins control dendritic spine morphology and density, which are cellular features often altered in autism spectrum disorder (ASD). Recent studies using animal models show that autism-related behavior can be rescued by either manipulating actin regulators or by reversing dendritic spine density or morphology. Based on these studies, the actin cytoskeleton is a potential target pathway for developing new ASD treatments. Thus, it is important to understand how ... 
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KW  - autism spectrum disorder; actin cytoskeleton; dendritic spines; inhibitory synapses; de novo point mutations; FRAGILE-X-SYNDROME; AUTISM SPECTRUM DISORDER; LONG-TERM POTENTIATION; SYNAPTIC PLASTICITY; MOUSE MODEL; MYOSIN IIB; GLUTAMATE RECEPTORS; PRUNING DEFICITS; IMAGE-ANALYSIS; KNOCKOUT MICE; 3112 Neurosciences; 3124 Neurology and psychiatry 
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