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T1  - Abdominal obesity and circulating metabolites : A twin study approach 
SN  -  /  
UR  - http://hdl.handle.net/10138/223885 
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A1  - Bogl, Leonie H.; Kaye, Sanna M.; Ramo, Joel T.; Kangas, Antti J.; Soininen, Pasi; Hakkarainen, Antti; Lundbom, Jesper; Lundbom, Nina; Ortega-Alonso, Alfredo; Rissanen, Aila; Ala-Korpela, Mika; Kaprio, Jaakko; Pietilainen, Kirsi H. 
A2  -  
PB  -  
Y1  - 2016 
LA  - eng 
AB  - Objective. To investigate how obesity, insulin resistance and low-grade inflammation link to circulating metabolites, and whether the connections are due to genetic or environmental factors. Subjects and methods. Circulating serum metabolites were determined by proton NMR spectroscopy. Data from 1368 (531 monozygotic (MZ) and 837 dizygotic (DZ)) twins were used for bivariate twin modeling to derive the genetic (r(g)) and environmental (re) correlations between waist circumference (WC) and serum ... 
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KW  - Twin study; Bivariate twin model; Genetic correlation; Serum metabolites; Obesity measures; CORONARY-ARTERY-DISEASE; FATTY-ACID-COMPOSITION; MIDDLE-AGED MEN; MONOZYGOTIC TWINS; CARDIOVASCULAR RISK; LIVER FAT; WOMEN; DISCORDANT; ADIPOSITY; PLASMA; 3121 General medicine, internal medicine and other clinical medicine 
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