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T1  - Aberrant intracellular calcium cycling in the heart : mechanistic insights into catecholaminergic polymorphic ventricular tachycardia and heart failure 
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UR  - URN:ISBN:978-952-10-9762-1; http://hdl.handle.net/10138/42853 
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A1  - Paavola, Jere 
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PB  - Helsingin yliopisto 
Y1  - 2014 
LA  - eng 
AB  - Heart disease is the biggest killer world-wide, causing a quarter of all deaths. During the past two decades, it has also risen above infectious diseases as the leading cause of years of life lost. Heart failure, characterized by weak pump function of the heart, and disturbances in heart rhythm (arrhythmias) are common and interrelated mechanisms underlying cardiac mortality. 

Intracellular calcium ions are crucial to contraction and relaxation of the heart muscle, as well as to control of its ... 
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