TY - T1 - Ability of matrix metalloproteinase-8 biosensor, IFMA, and ELISA immunoassays to differentiate between periodontal health, gingivitis, and periodontitis SN - / UR - http://hdl.handle.net/10138/348411 T3 - A1 - Umeizudike, Kehinde Adesola; Lähteenmäki, Hanna; Räisänen, Ismo T.; Taylor, John J.; Preshaw, Philip M.; Bissett, Susan M.; Tervahartiala, Taina; O Nwhator, Solomon; Pärnänen, Pirjo; Sorsa, Timo A2 - PB - Y1 - 2022 LA - eng AB - Objective: The aim of this study was to determine the diagnostic utility of an MMP-8 biosensor assay in differentiating periodontal health from gingivitis and periodontitis and compare it with an established time-resolved immunofluorescence assay (IFMA) and enzyme-linked immunosorbent assay (ELISA). Background: Currently available antibody-based assays display a wide variability in their ability to accurately measure matrix metalloproteinase-8 (MMP-8) levels in saliva. Methods: Salivary MMP-8 le... VO - IS - SP - OP - KW - active/total matrix metalloproteinase-8; saliva; biosensor; periodontal disease; total matrix metalloproteinase-8; GLOBAL BURDEN; DIAGNOSIS; NEUTROPHIL COLLAGENASE ACTIVITY; INTERSTITIAL COLLAGENASES; MOUTHRINSE; active; CLASSIFICATION; ADULT PERIODONTITIS; saliva; TISSUE DESTRUCTION; CREVICULAR FLUID; MMP-8; 313 Dentistry N1 - PP - ER -