TY - T1 - Actin regulation in dendritic spines : from synaptic plasticity to animal behavior and human neurodevelopmental disorders SN - / UR - URN:ISBN:978-951-51-5356-2; http://hdl.handle.net/10138/303934 T3 - A1 - Hlushchenko, Iryna A2 - PB - Helsingin yliopisto Y1 - 2019 LA - eng AB - This thesis explores the role of several actin-binding proteins in the regulation of brain physiology with a focus on dendritic spines. Dendritic spines are considered the plausible physical substrate for learning and memory, as their morphology allows for modulating incoming signals. Disruptions in spine density and morphology are also often associated with neuropsychiatric disorders. The two cellular processes representing neuronal learning are long-term potentiation (LTP) and long-term depr... VO - IS - SP - OP - KW - Physiology and Neuroscience N1 - PP - ER -