TY - T1 - Action and function of Akkermansia muciniphila in microbiome ecology, health and disease SN - / UR - http://hdl.handle.net/10138/301990 T3 - A1 - Ottman, Noora; Geerlings, Sharon Y.; Aalvink, Steven; de Vos, Willem M.; Belzer, Clara A2 - PB - Y1 - 2017 LA - eng AB - The discovery of Akkermansia muciniphila has opened new avenues for the use of this abundant intestinal symbiont in next generation therapeutic products, as well as targeting microbiota dynamics. A. muciniphila is known to colonize the mucosal layer of the human intestine where it triggers both host metabolic and immune responses. A. muciniphila is particularly effective in increasing mucus thickness and increasing gut barrier function. As a result host metabolic markers ameliorate. The mechanis... VO - IS - SP - OP - KW - Akkermansia muciniphila; Microbiome; Mucus; Pharmabiotic; Probiotic; INFLAMMATORY BOWEL DISEASES; SULFATE-REDUCING BACTERIA; GUT MICROBIOTA; INTESTINAL MICROBIOTA; BACTEROIDES-THETAIOTAOMICRON; ENTERIC PATHOGENS; DIETARY FIBER; MUCUS BARRIER; MUCIN; COLON; 3121 General medicine, internal medicine and other clinical medicine N1 - PP - ER -