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T1  - Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism 
SN  -  /  
UR  - http://hdl.handle.net/10138/337341 
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A1  - Karpale, M; Karajamaki, AJ; Kummu, O; Gylling, H; Hyotylainen, T; Oresic, M; Tolonen, A; Hautajarvi, H; Savolainen, MJ; Ala-Korpela, M; Hukkanen, J; Hakkola, J 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Background and Purpose Many drugs and environmental contaminants induce hypercholesterolemia and promote the risk of atherosclerotic cardiovascular disease. We tested the hypothesis that pregnane X receptor (PXR), a xenobiotic-sensing nuclear receptor, regulates the level of circulating atherogenic lipids in humans and utilized mouse experiments to identify the mechanisms involved. Experimental Approach We performed serum NMR metabolomics in healthy volunteers administered rifampicin, a prototyp... 
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KW  - cholesterol; hypercholesterolemia; lathosterol; LDL; PCSK9; PXR; SREBP2; HMG-COA REDUCTASE; MAGNETIC-RESONANCE METABOLOMICS; BILE-ACID SYNTHESIS; GLUCOSE-HOMEOSTASIS; INSULIN-RESISTANCE; CHOLESTEROL LEVELS; ENZYME-INDUCTION; CONCISE GUIDE; SERUM-LEVELS; METABOLISM; 3111 Biomedicine 
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