TY  -  
T1  - Addressing the Biochemical Foundations of a Glucose-Based "Trojan Horse"-Strategy to Boron Neutron Capture Therapy : From Chemical Synthesis to In Vitro Assessment 
SN  -  /  
UR  - http://hdl.handle.net/10138/321501 
T3  -  
A1  - Matovic, Jelena; Järvinen, Juulia; Bland, Helena C.; Sokka, Iris K.; Imlimthan, Surachet; Ferrando, Ruth Mateu; Huttunen, Kristiina M.; Timonen, Juri; Peräniemi, Sirpa; Aitio, Olli; Airaksinen, Anu J.; Sarparanta, Mirkka; Johansson, Mikael P.; Rautio, Jarkko; Ekholm, Filip S. 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Boron neutron capture therapy (BNCT) for cancer is on the rise worldwide due to recent developments of in-hospital neutron accelerators which are expected to revolutionize patient treatments. There is an urgent need for improved boron delivery agents, and herein we have focused on studying the biochemical foundations upon which a successful GLUT1-targeting strategy to BNCT could be based. By combining synthesis and molecular modeling with affinity and cytotoxicity studies, we unravel the mechani... 
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KW  - boron neutron capture therapy; cancer therapeutics; carbohydrates; glucose transporters; medicinal chemistry; drug delivery; SQUAMOUS-CELL CARCINOMA; NECK-CANCER; CRYSTAL-STRUCTURE; RECURRENT HEAD; FORCE-FIELD; BASIS-SETS; TRANSPORTERS; DERIVATIVES; CONFORMATION; RECOGNITION; 116 Chemical sciences; 317 Pharmacy 
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