TY - T1 - Adenoviral CD40 Ligand Immunotherapy in 32 Canine Malignant Melanomas-Long-Term Follow Up SN - / UR - http://hdl.handle.net/10138/334631 T3 - A1 - Saellstrom, Sara; Sadeghi, Arian; Eriksson, Emma; Segall, Thomas; Dimopoulou, Maria; Korsgren, Olle; Loskog, Angelica SI.; Totterman, Thomas H.; Hemminki, Akseli; Ronnberg, Henrik A2 - PB - Y1 - 2021 LA - eng AB - Malignant melanoma is a serious disease in both humans and dogs, and the high metastatic potential results in poor prognosis for many patients. Its similarities with human melanoma make spontaneous canine melanoma an excellent model for comparative studies of novel therapies and tumor biology. Gene therapy using adenoviruses encoding the immunostimulatory gene CD40L (AdCD40L) has shown promise in initial clinical trials enrolling human patients with various malignancies including melanoma. We re... VO - IS - SP - OP - KW - immuno oncology; adenoviral vectors; translational medicine; canine malignant melanoma; clinical trials; AdCD40L; LOW-DOSE CYCLOPHOSPHAMIDE; ADCD40L GENE-THERAPY; SURGICAL EXCISION; DENDRITIC CELLS; CANCER BIOLOGY; DOGS; TUMORS; SURVIVAL; BEHAVIOR; VACCINE; 413 Veterinary science N1 - PP - ER -