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T1  - Adipokine Leptin Co-operates With Mechanosensitive Ca2+-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells 
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UR  - http://hdl.handle.net/10138/326360 
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A1  - Acheva, Anna; Kärki, Tytti; Schaible, Niccole; Krishnan, Ramaswamy; Tojkander, Sari 
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PB  -  
Y1  - 2021 
LA  - eng 
AB  - In postmenopausal women, a major risk factor for the development of breast cancer is obesity. In particular, the adipose tissue-derived adipokine leptin has been strongly linked to tumor cell proliferation, migration, and metastasis, but the underlying mechanisms remain unclear. Here we show that treatment of normal mammary epithelial cells with leptin induces EMT-like features characterized by higher cellular migration speeds, loss of structural ordering of 3D-mammo spheres, and enhancement of ... 
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KW  - adipokines; actomyosin; calcium; actin; epithelium; MESENCHYMAL TRANSITION; CANCER CELLS; MYOSIN-II; MOLECULAR-MECHANISMS; CONTRACTILE FORCES; ADIPONECTIN; ADIPOCYTES; EXPRESSION; INVASION; RECEPTOR; 1182 Biochemistry, cell and molecular biology; 3122 Cancers 
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