TY  -  
T1  - Adrenals Contribute to Growth of Castration-Resistant VCaP Prostate Cancer Xenografts 
SN  -  /  
UR  - http://hdl.handle.net/10138/307082 
T3  -  
A1  - Huhtaniemi, Riikka; Oksala, Riikka; Knuuttila, Matias; Mehmood, Arfa; Aho, Eija; Laajala, Teemu D.; Nicorici, Daniel; Aittokallio, Tero; Laiho, Asta; Elo, Laura; Ohlsson, Claes; Kallio, Pekka; Mäkelä, Sari; Mustonen, Mika V. J.; Sipila, Petra; Poutanen, Matti 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - The role of adrenal androgens as drivers for castration-resistant prostate cancer (CRPC) growth in humans is generally accepted; however, the value of preclinical mouse models of CRPC is debatable, because mouse adrenals do not produce steroids activating the androgen receptor. In this study, we confirmed the expression of enzymes essential for de novo synthesis of androgens in mouse adrenals, with high intratissue concentration of progesterone (P-4) and moderate levels of androgens, such as and... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - ANDROGEN RECEPTOR EXPRESSION; ABIRATERONE ACETATE; HORMONE AGONISTS; MECHANISMS; STEROIDOGENESIS; ENZALUTAMIDE; GENE; ANTIANDROGENS; BIOCONDUCTOR; TESTOSTERONE; 3111 Biomedicine 
N1  -   
PP  -  
ER  -