TY  -  
T1  - Altered regulation and expression of genes by BET family of proteins in COPD patients 
SN  -  /  
UR  - http://hdl.handle.net/10138/178656 
T3  -  
A1  - Malhotra, Rajneesh; Kurian, Nisha; Zhou, Xiao-Hong; Jiang, Fanyi; Monkley, Susan; DeMicco, Amy; Clausen, Ib G.; Dellgren, Göran; Edenro, Goran; Ahdesmaki, Miika J.; Clausen, Maryam; Oberg, Lisa; Israelsson, Elisabeth; Belfield, Graham; Vaarala, Outi 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Background BET proteins (BRD2, BRD3, BRDT and BRD4) belong to the family of bromodomain containing proteins, which form a class of transcriptional co-regulators. BET proteins bind to acetylated lysine residues in the histones of nucleosomal chromatin and function either as co-activators or co-repressors of gene expression. An imbalance between HAT and HDAC activities resulting in hyperacetylation of histones has been identified in COPD. We hypothesized that pan-BET inhibitor (JQ1) treatment of B... 
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IS  -  
SP  -  
OP  -  
KW  - OBSTRUCTIVE PULMONARY-DISEASE; BROMODOMAIN INHIBITION; CIGARETTE-SMOKE; LIPOPOLYSACCHARIDE; RESPONSES; GENETICS; REVEALS; CELLS; 3111 Biomedicine 
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ER  -