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T1  - Alternative oxidase confers nutritional limitation on Drosophila development 
SN  -  /  
UR  - http://hdl.handle.net/10138/326580 
T3  -  
A1  - Saari, Sini; Kemppainen, Esa; Tuomela, Tero; Oliveira, M.T.; Dufour, E.; Jacobs, H.T. 
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Y1  - 2019 
LA  - eng 
AB  - The mitochondrial alternative oxidase, AOX, present in most eukaryotes apart from vertebrates and insects, catalyzes the direct oxidation of ubiquinol by oxygen, by-passing the terminal proton-motive steps of the respiratory chain. Its physiological role is not fully understood, but it is proposed to buffer stresses in the respiratory chain similar to those encountered in mitochondrial diseases in humans. Previously, we found that the ubiquitous expression of AOX from Ciona intestinalis in Droso... 
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KW  - AOX; cataplerosis; mitochondria; nutrition; TCA cycle; alternative oxidase; Drosophila protein; mitochondrial protein; molasses; oxidoreductase; plant protein; animal; animal food; Ciona intestinalis; diet; Drosophila; enzymology; genetics; growth, development and aging; HEK293 cell line; human; larva; metabolism; metamorphosis; mitochondrion; transgenic animal; Animal Nutritional Physiological Phenomena; Animals; Animals, Genetically Modified; Diet; Drosophila Proteins; HEK293 Cells; Humans; Larva; Metamorphosis, Biological; Mitochondria; Mitochondrial Proteins; Molasses; Oxidoreductases; Plant Proteins; 1182 Biochemistry, cell and molecular biology; 413 Veterinary science 
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