TY  -  
T1  - Amyloid and the origin of life : self-replicating catalytic amyloids as prebiotic informational and protometabolic entities 
SN  -  /  
UR  - http://hdl.handle.net/10138/234616 
T3  -  
A1  - Maury, Carl Peter J. 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - A crucial stage in the origin of life was the emergence of the first molecular entity that was able to replicate, transmit information, and evolve on the early Earth. The amyloid world hypothesis posits that in the pre-RNA era, information processing was based on catalytic amyloids. The self-assembly of short peptides into beta-sheet amyloid conformers leads to extraordinary structural stability and novel multifunctionality that cannot be achieved by the corresponding nonaggregated peptides. The... 
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IS  -  
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KW  - Origin-of-life theory; Amyloid world; RNA world; Prion; Molecular evolution; Primordial genetics; RNA WORLD; FIBRIL FORMATION; LIPID-MEMBRANES; NUCLEIC-ACID; SECONDARY NUCLEATION; GELSOLIN PEPTIDES; PRIMORDIAL EARTH; PRION PROTEIN; AMINO-ACIDS; BETA-SHEETS; 1182 Biochemistry, cell and molecular biology; 3111 Biomedicine 
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ER  -