TY  -  
T1  - An RGS2 3'UTR Polymorphism is Associated with Preeclampsia in Overweight Women 
SN  -  /  
UR  - URN:NBN:fi:hulib-201611012943; http://hdl.handle.net/10138/169756 
T3  -  
A1  - Karppanen, Tiina; Kaartokallio, Tea; Heinonen, Seppo; Kajantie, Eero; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Staff, Anne Cathrine; Laivuori, Hannele; Klemetti, Miira M. 
A2  -  
PB  - Helsingfors universitet 
Y1  - 2016 
LA  - eng 
AB  - Background

Preeclampsia is a common and heterogeneous vascular syndrome of pregnancy. Its genetic risk profile is yet unknown and may vary between individuals and populations. The rs4606 3' UTR polymorphism of the Regulator of G-protein signaling 2 gene (RGS2) in the mother has been implicated in preeclampsia as well as in the development of chronic hypertension after preeclampsia. The RGS2 protein acts as an inhibitor of physiological vasoconstrictive pathways, and a low RGS2 level is associat... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - preeclampsia; pregnancy; regulator of G-protein signaling 2; candidate gene study; Medical Genetics; Lääketieteellinen genetiikka ja perinnöllisyyslääketiede; Medicinsk genetik 
N1  -   
PP  -  
ER  -