TY - T1 - Anti-EDAR Agonist Antibody Therapy Resolves Palate Defects in Pax9 -/- Mice SN - / UR - http://hdl.handle.net/10138/299388 T3 - A1 - Jia, S.; Zhou, J.; Wee, Y.; Mikkola, M. L.; Schneider, P.; D'Souza, R. N. A2 - PB - Y1 - 2017 LA - eng AB - To date, surgical interventions are the only means by which craniofacial anomalies can be corrected so that function, esthetics, and the sense of well-being are restored in affected individuals. Unfortunately, for patients with cleft palate-one of the most common of congenital birth defects-treatment following surgery is prolonged over a lifetime and often involves multidisciplinary regimens. Hence, there is a need to understand the molecular pathways that control palatogenesis and to translate ... VO - IS - SP - OP - KW - developmental biology; cleft palate; craniofacial biology/genetics; morphogenesis; gene expression; therapeutic treatment; LINKED ECTODERMAL DYSPLASIA; HAIR FOLLICLE INDUCTION; RECEPTOR EDAR; CLEFT-LIP; KAPPA-B; ECTODYSPLASIN; MORPHOGENESIS; BMP4; MSX1; PAX9; 313 Dentistry N1 - PP - ER -