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T1  - Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients 
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UR  - http://hdl.handle.net/10138/235312 
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A1  - Polonen, R. P.; Penttinen, K.; Swan, H.; Aalto-Setälä, K. 
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Y1  - 2018 
LA  - eng 
AB  - Mutations in the cardiac ryanodine receptor (RYR2) are the leading cause for catecholaminergic polymorphic ventricular tachycardia (CPVT). In this study, we evaluated antiarrhythmic efficacy of carvedilol and flecainide in CPVT patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) carrying different mutations in RYR2. iPSC-CMs were generated from skin biopsies of CPVT patients carrying exon 3 deletion and IA115 or V4653F mutation in RYR2 and of a healthy individual. Ca... 
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KW  - CARDIAC RYANODINE RECEPTOR; INDUCED CA2+ RELEASE; MECHANISM; MODEL; RYR2; THRESHOLD; THERAPY; TRIAL; WAVES; CPVT; 3121 General medicine, internal medicine and other clinical medicine 
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