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T1  - Antiproliferative Activity and Cellular Uptake of Evodiamine and Rutaecarpine based on 3D Tumour Models 
SN  -  /  
UR  - http://hdl.handle.net/10138/166523 
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A1  - Guo, Hui; Liu , Dongmei; Gao , Bin; Zhang, Xiaohui; You, Minli; Ren, Hui; Zhang, Hongbo; Almeida Santos, Helder; Xu , Feng 
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PB  -  
Y1  - 2016 
LA  - eng 
AB  - Evodiamine (EVO) and rutaecarpine (RUT) are promising anti-tumor drug candidates. The evaluation of the anti-proliferative activity and cellular uptake of EVO and RUT in 3D multicellular spheroids of cancer cells would better recapitulate the native situation and thus better reflect an in vivo response to the treatment. Herein, we employed the 3D culture of MCF-7 and SMMC-7721 cells based on hanging drop method and evaluated the anti-proliferative activity and cellular uptake of EVO and RUT in 3... 
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KW  - 317 Pharmacy; 116 Chemical sciences; cellular uptake; auto-fluorescence; 3D multicellular spheroids; hanging drop method; IN-VITRO; BREAST-CANCER; DRUG DISCOVERY; CELLS; CAMPTOTHECIN; DERIVATIVES; APOPTOSIS; LINES; TRANSFORMATION; MECHANISM 
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