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T1  - Apolipoprotein A-I concentrations and risk of coronary artery disease : A Mendelian randomization study 
SN  -  /  
UR  - http://hdl.handle.net/10138/314840 
T3  -  
A1  - Karjalainen, Minna K.; Holmes, Michael V.; Wang, Qin; Anufrieva, Olga; Kähönen, Mika; Lehtimäki, Terho; Havulinna, Aki S.; Kristiansson, Kati; Salomaa, Veikko; Perola, Markus; Viikari, Jorma S.; Raitakari, Olli T.; Järvelin, Marjo-Riitta; Ala-Korpela, Mika; Kettunen, Johannes 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Background and aims: Apolipoprotein A-I (apoA-I) infusions represent a potential novel therapeutic approach for the prevention of coronary artery disease (CAD). Although circulating apoA-I concentrations inversely associate with risk of CAD, the evidence base of this representing a causal relationship is lacking. The aim was to assess the causal role of apoA-I using human genetics. Methods: We identified a variant (rs12225230) in APOA1 locus that associated with circulating apoA-I concentrations... 
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IS  -  
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KW  - Apolipoprotein; Heart disease; Lipids; Mendelian randomization; LIPOPROTEIN CHOLESTEROL LEVELS; GENETIC INHIBITION; EFFLUX CAPACITY; APOA-I; CSL112; ATHEROSCLEROSIS; FORMULATION; HDL; 3121 General medicine, internal medicine and other clinical medicine 
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ER  -