TY  -  
T1  - Association of Human FOS Promoter Variants with the Occurrence of Knee-Osteoarthritis in a Case Control Association Study 
SN  -  /  
UR  - http://hdl.handle.net/10138/301570 
T3  -  
A1  - Huber, Rene; Kirsten, Holger; Näkki, Annu; Pohlers, Dirk; Thude, Hansjoerg; Eidner, Thorsten; Heinig, Matthias; Brand, Korbinian; Ahnert, Peter; Kinne, Raimund W. 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Our aim was to analyse (i) the presence of single nucleotide polymorphisms (SNPs) in the JUN and FOS core promoters in patients with rheumatoid arthritis (RA), knee-osteoarthritis (OA), and normal controls (NC); (ii) their functional influence on JUN/FOS transcription levels; and (iii) their associations with the occurrence of RA or knee-OA. JUN and FOS promoter SNPs were identified in an initial screening population using the Non-Isotopic RNase Cleavage Assay (NIRCA); their functional influence... 
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IS  -  
SP  -  
OP  -  
KW  - AP-1; JUN; FOS; promoter; knee osteoarthritis; SINGLE-BASE EXTENSION; RHEUMATOID-ARTHRITIS; SYNOVIAL FIBROBLASTS; CELL-PROLIFERATION; C-FOS; EXPRESSION; CLASSIFICATION; PATHOGENESIS; 1182 Biochemistry, cell and molecular biology 
N1  -   
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ER  -