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T1  - Association of deranged cerebrovascular reactivity with brain injury following cardiac arrest : a post-hoc analysis of the COMACARE trial 
SN  -  /  
UR  - http://hdl.handle.net/10138/336546 
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A1  - Laurikkala, Johanna; Aneman, Anders; Peng, Alexander; Reinikainen, Matti; Pham, Paul; Jakkula, Pekka; Hästbacka, Johanna; Wilkman, Erika; Loisa, Pekka; Toppila, Jussi; Birkelund, Thomas; Blennow, Kaj; Zetterberg, Henrik; Skrifvars, Markus B. 
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PB  -  
Y1  - 2021 
LA  - eng 
AB  - Background: Impaired cerebrovascular reactivity (CVR) is one feature of post cardiac arrest encephalopathy. We studied the incidence and features of CVR by near infrared spectroscopy (NIRS) and associations with outcome and biomarkers of brain injury. Methods: A post-hoc analysis of 120 comatose OHCA patients continuously monitored with NIRS and randomised to low- or high-normal oxygen, carbon dioxide and mean arterial blood pressure (MAP) targets for 48 h. The tissue oximetry index-(TOx) genera... 
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KW  - Cerebrovascular reactivity; Out-of-hospital cardiac arrest; Hypoxic-ischaemic brain injury; NEAR-INFRARED SPECTROSCOPY; CEREBRAL-BLOOD-FLOW; MEAN ARTERIAL-PRESSURE; INTENSIVE-CARE-UNIT; AUTOREGULATION; OXYGEN; TIME; RESUSCITATION; TARGETS; 3126 Surgery, anesthesiology, intensive care, radiology; 3121 General medicine, internal medicine and other clinical medicine 
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