TY - T1 - Association of plasma gelsolin with frailty phenotype and mortality among octogenarian community-dwelling men : a cohort study SN - / UR - http://hdl.handle.net/10138/345171 T3 - A1 - Strandberg, Timo E.; Levinson, Susan L.; DiNubile, Mark J.; Jyväkorpi, Satu; Kivimäki, Mika A2 - PB - Y1 - 2022 LA - eng AB - Background Biomarkers are needed for frailty, a common phenotype often associated with muscle loss in older people. Plasma gelsolin (pGSN) is a protein largely synthesized and secreted by skeletal muscle. Aims To investigate whether pGSN could be a biomarker of the frailty phenotype and predict mortality. Methods A homogenous cohort of males (born 1919-1934, baseline n = 3490) has been followed since the 1960s. In 2010/11, frailty phenotypes by modified Fried criteria were assessed. pGSN was mea... VO - IS - SP - OP - KW - Biomarker; Prefrailty; Sarcopenia; MARKER; MUSCLE; 3111 Biomedicine; 3121 General medicine, internal medicine and other clinical medicine N1 - PP - ER -