TY  -  
T1  - Association of tamoxifen resistance and lipid reprogramming in breast cancer 
SN  -  /  
UR  - http://hdl.handle.net/10138/243415 
T3  -  
A1  - Hultsch, Susanne; Kankainen, Matti; Paavolainen, Lassi; Kovanen, Ruusu-Maaria; Ikonen, Elina; Kangaspeska, Sara; Pietiäinen, Vilja; Kallioniemi, Olli 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Background: Tamoxifen treatment of estrogen receptor (ER)-positive breast cancer reduces mortality by 31%. However, over half of advanced ER-positive breast cancers are intrinsically resistant to tamoxifen and about 40% will acquire the resistance during the treatment. Methods: In order to explore mechanisms underlying endocrine therapy resistance in breast cancer and to identify new therapeutic opportunities, we created tamoxifen-resistant breast cancer cell lines that represent the luminal A o... 
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OP  -  
KW  - Tamoxifen resistance; Breast cancer; Lysosomal membrane permeabilization; RNA-sequencing; Drug sensitivity and resistance testing; LYSOSOMAL CELL-DEATH; RECEPTOR-ACTIVITY; IMAGE-ANALYSIS; BINDING-SITE; CATHEPSIN-D; EXPRESSION; METABOLISM; MECHANISMS; MUTATIONS; GENE; 3122 Cancers 
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ER  -