TY  -  
T1  - Associations Between IFI44L Gene Variants and Rates of Respiratory Tract Infections During Early Childhood 
SN  -  /  
UR  - http://hdl.handle.net/10138/331643 
T3  -  
A1  - Lempainen, Johanna; Korhonen, Laura S.; Kantojärvi, Katri; Heinonen, Santtu; Toivonen, Laura; Räty, Panu; Ramilo, Octavio; Mejias, Asuncion; Vuorinen, Tytti; Waris, Matti; Karlsson, Linnea; Karlsson, Hasse; Laine, Antti-Pekka; Paunio, Tiina; Peltola, Ville 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Background. Genetic heterogeneity in type I interferon (IFN)-related gene IFI44L may account for variable susceptibility to respiratory tract infections (RTIs) in children. Methods. In 2 prospective, population-based birth cohorts, the STEPS Study and the FinnBrain Birth Cohort Study, IFI44L genotypes for rs273259 and rs1333969 were determined in relation to the development of RTIs until 1 or 2 years of age, respectively. At age 3 months, whole-blood transcriptional profiles were analyzed and na... 
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KW  - 3111 Biomedicine; acute otitis media; interferon pathway; polymorphisms; respiratory tract infections; transcriptome; COHORT PROFILE; OTITIS-MEDIA; POLYMORPHISMS; CHILDREN; COMPLICATION; SYMPTOMS; TOOL 
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