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T1  - Asymmetry in catalysis by Thermotoga maritima membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor 
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UR  - http://hdl.handle.net/10138/303494 
T3  -  
A1  - Vidilaseris, Keni; Kiriazis, Alexandros; Turku, Ainoleena; Khattab, Ayman Abdelnaby Shaaban; Johansson, Niklas G; Leino, Teppo Olavi; Kiuru, Paula Sinikka; Boije af Gennäs, Per Gustav; Meri, Seppo Kalevi; Yli-Kauhaluoma, Jari Tapani; Xhaard, Henri Guillaume Michel; Goldman, Adrian 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Membrane-bound pyrophosphatases are homodimeric integral membrane proteins that hydrolyze pyrophosphate into orthophosphates, coupled to the active transport of protons or sodium ions across membranes. They are important in the life cycle of bacteria, archaea, plants, and parasitic protists, but no homologous proteins exist in vertebrates, making them a promising drug target. Here, we report the first nonphosphorus allosteric inhibitor of the thermophilic bacterium Thermotoga maritima membrane-b... 
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KW  - ACIDOCALCISOMES; BISPHOSPHONATES; EVOLUTIONARY CONSERVATION; INORGANIC PYROPHOSPHATASE; LEISHMANIA-DONOVANI; LOCALIZATION; PLASMODIUM-FALCIPARUM; TOXOPLASMA-GONDII; TRYPANOSOMA-BRUCEI; VACUOLAR-H+-PYROPHOSPHATASE; 317 Pharmacy 
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