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T1  - Axonal Kainate Receptors Modulate the Strength of Efferent Connectivity by Regulating Presynaptic Differentiation 
SN  -  /  
UR  - http://hdl.handle.net/10138/182583 
T3  -  
A1  - Sakha, Prasanna; Vesikansa, Aino; Orav, Ester; Heikkinen, Joonas; Kukko-Lukjanov, Tiina-Kaisa; Shintyapina, Alexandra; Franssila, Sami; Jokinen, Ville; Huttunen, Henri J.; Lauri, Sari E. 
A2  -  
PB  -  
Y1  - 2016 
LA  - eng 
AB  - Kainate type of glutamate receptors (KARs) are highly expressed during early brain development and may influence refinement of the circuitry, via modulating synaptic transmission and plasticity. KARs are also localized to axons, however, their exact roles in regulating presynaptic processes remain controversial. Here, we have used a microfluidic chamber system allowing specific manipulation of KARs in presynaptic neurons to study their functions in synaptic development and function in vitro. Sil... 
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KW  - glutamate receptor; kainate receptor; presynaptic; glutamate release probability; microfluidic; synaptogenesis; MOSSY FIBER SYNAPSES; CULTURED HIPPOCAMPAL-NEURONS; SYNAPTIC VESICLES; GROWTH CONE; MATURATION; ACTIVATION; MOTILITY; SYNAPTOGENESIS; PLASTICITY; DYNAMICS; 3112 Neurosciences 
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