TY  -  
T1  - Behavior of the DPH fluorescence probe in membranes perturbed by drugs 
SN  -  /  
UR  - http://hdl.handle.net/10138/305563 
T3  -  
A1  - Poojari, Chetan; Wilkosz, Natalia; Lira, Rafael B.; Dimova, Rumiana; Jurkiewicz, Piotr; Petka, Rafal; Kepczynski, Mariusz; Rog, Tomasz 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - 1,6-Diphenyl-1,3,5-hexatriene (DPH) is one of the most commonly used fluorescent probes to study dynamical and structural properties of lipid bilayers and cellular membranes via measuring steady-state or time-resolved fluorescence anisotropy. In this study, we present a limitation in the use of DPH to predict the order of lipid acyl chains when the lipid bilayer is doped with itraconazole (ITZ), an antifungal drug. Our steady-state fluorescence anisotropy measurements showed a significant decrea... 
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IS  -  
SP  -  
OP  -  
KW  - 1,6-diphenyl-1,3,5-hexatriene; Lipid bilayers; Molecular dynamics simulations; Fluorescence anisotropy; PARTICLE MESH EWALD; AA FORCE-FIELD; BIOPHYSICAL PROPERTIES; MODEL MEMBRANES; LIPID-MEMBRANES; STAPHYLOCOCCUS-AUREUS; UNILAMELLAR VESICLES; CHOLESTEROL; DYNAMICS; DPPC; 114 Physical sciences; 116 Chemical sciences 
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ER  -