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T1  - Beta2-Integrins and Interacting Proteins in Leukocyte Trafficking, Immune Suppression, and Immunodeficiency Disease 
SN  -  /  
UR  - http://hdl.handle.net/10138/299951 
T3  -  
A1  - Fagerholm, Susanna C.; Guenther, Carla; Asens, Marc Llort; Savinko, Terhi; Uotila, Liisa M. 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Beta2-integrins are complex leukocyte-specific adhesion molecules that are essential for leukocyte (e.g., neutrophil, lymphocyte) trafficking, as well as for other immunological processes such as neutrophil phagocytosis and ROS production, and T cell activation. Intriguingly, however, they have also been found to negatively regulate cytokine responses, maturation, and migratory responses in myeloid cells such as macrophages and dendritic cells, revealing new, and unexpected roles of these molecu... 
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IS  -  
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KW  - integrin; trafficking; kindlin-3; leukocyte adhesion deficiency; leukocyte adhesion cascade; T-CELL-ACTIVATION; ADHESION DEFICIENCY TYPE-1; BETA(2) INTEGRINS; NEUTROPHIL RECRUITMENT; CYTOPLASMIC TAIL; MAC-1 CD11B/CD18; DENDRITIC CELLS; DISTINCT; LFA-1; RESPONSES; 3111 Biomedicine 
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ER  -